Glyceryl Modification

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Applicable Products

2326 3'-Glyceryl SynBase CPG 1000

Physical Data

Item

Mol. Formula

Mol. Wt.

Unit Wt.

2236 - - 154.06

Coupling

As with all non-nucleosidic supports, an additional deblock step is required.

Cleavage & Deprotection

This is dependent on the nucleobase protection and other modifications but is typically ammonium hydroxide at 55ºC for 4h, or AMA at 65ºC for 10min.

Storage & Stability

Store dry in a freezer at –10 to –30°C.

References

  1. For oxidation and reduction methods for converting the glycerol group, see: Convenient synthesis of oligonucleotides with a 3’-phosphoglycolate and 3’-phosphoglycaldehyde terminus, H. Urata and M. Akagi, Tetrahedron Lett., 34, 4015-4018 (1993). [Abtract]
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